Leman Biotech Announces Oral Presentation of IIT Clinical Trial Results for Metabolically Armed CD19 CAR-T Cells at AACR 2024


Lausanne, March 27, 2024 - Leman Biotech, a clinical-stage biotechnology company focusing on the development, production, and commercialization of innovative metabolic immunotherapies, will deliver an oral presentation at the American Association of Cancer Research (AACR) annual meeting, to be held in San Diego, CA, from April 5th to 10th, 2024. We will present clinical results from our first-in-human investigator-initiated clinical trials for Metabolically Armed CD19 CAR-T Cell therapy for relapsed or refractory B cell hematological malignancies. Our Co-Founder and President Prof. Li Tang and Translational Research Director of our Swiss Research Center Dr. Karthik Sathiyanadan will attend the meeting. Our Associate Director of R&D Dr. Jingjing Ren will deliver the presentation.


Details of the presentation

Session: LBMS01 - Minisymposium: Late-Breaking Research

Time: Monday, April 8, 2024, 3:50 PM - 4:05 PM (PDT)       

Title: LB236 - Metabolically armed CD19 CAR-T cells for safe and effective treatment of relapsed or refractory CD19+ B cell hematological malignancies at extremely low doses.

Link: https://www.abstractsonline.com/pp8/#!/20272/presentation/11336 


Meta 10 Technology

Leman Biotech's Metabolic Reprogramming Technology (Meta 10) is an innovative approach to combatting T-cell exhaustion. Preclinical studies shown its ability to activate the oxidative phosphorylation metabolism in terminally exhausted T cells, restoring their proliferative potential and cytotoxic activity. Promising preclinical results include tumor clearance in various mouse models and induction of stem-like immune memory cells. Leman Biotech has launched investigator initiated clinical trial for metabolically armed CD19 CAR-T therapy (Meta10-19 CAR-T) for patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) and acute B-lymphoblastic leukemia (r/r B-ALL) in early 2023. All patients treated with Meta 10-19 CAR-T have shown complete responses at a low dose, with minimal side effects. These findings underscore Meta 10's immense clinical potential.


About Leman Biotech

Leman Biotech is a clinical-stage cancer immunotherapy company co-founded by Professor Li Tang of the Swiss Federal Institute of Technology in Lausanne (EPFL) and AI-driven drug R&D leader XtalPi. The company combines innovative metabolic reprogramming technology with a cutting-edge AI drug discovery platform to develop next-generation cancer immunotherapies. The core technology, Meta 10, has the potential to cure solid tumors, as demonstrated in published research in top academic journals such as Nature Immunology and Nature Biotechnology. Additionally, it holds PCT patents covering major economies worldwide. Leman Biotech completed a successful angel plus round of financing, raising nearly $18 million in total, with plans for further financing underway. The company is committed to finding solutions to tackling the bottlenecks in cancer immunotherapy, improving response rates and efficacy, and making unremitting efforts to achieve the ultimate goal of curing cancer.

Website: https://www.lemanbio.com/en