Patents
1.“IL10/FC fusion proteins useful as enhancers of immunotherapies” #EP 19198358.4; #PCT/EP2020/076089; Inventors: GUO, Yugang; TANG, Li; XIE, Yu-Qing.
2.“IL-10 expressing cells for enhanced cancer immunotherapies” #EP 21192853.6; Inventors: GUO, Yugang; TANG, Li; ZHAO, Yang.
3.“一种治疗性肿瘤浸润淋巴细胞及其制备方法和应用” 申请号：2022116769776; 申请人：深圳莱芒生物科技有限公司。
4.“一种白细胞介素10的突变体及其制备方法和应用” 申请号：2022116277856; 申请人：深圳莱芒生物科技有限公司。
Publications
1. Guo, Y. et al. Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity. Nat Immunol. 22, 746-756 (2021).
2. Zhao, Y. et al. Switchable immune modulator for tumor-specific activation of anticancer immunity. Sci. Adv. 9, 1–16 (2021).
3. Guo, Y. et al. Purification and characterization of human IL-10/Fc fusion protein expressed in Pichia pastoris. Protein Expr. Purif. 83, 152–156 (2012).
