Lausanne, November 14, 2024 - Leman Biotech, a clinical-stage biotechnology company focusing on the development, production, and commercialization of innovative metabolic immunotherapies, will deliver an oral presentation at the 7th Swiss Oncology & Hematology Congress (SOHC) 2024 annual meeting, to be held in Congress Center Basel, Switzerland, from November 20 - 22, 2024. We will present the clinical results from our first-in-human investigator-initiated clinical trials for Metabolically Armed CD19 CAR-T Cell therapy for relapsed or refractory B cell hematological malignancies. Our Director of Translational Research Dr. Karthik Sathiyanadan will deliver the presentation.
Details of the presentation:
Session: Oral presentations Clinical hemato-oncology
Abstract: 322 - IL-10 Expressing CD19 CAR-T Cells Induce Complete Remission and Improve Long-term Protection in Relapsed or Refractory B-Cell Hematological Malignancies
Time: Wednesday, November 20, 2024, 3:45 PM - 5:15 PM
Room: Shanghai 1-2 – Congress Center Basel
Link: https://www.sohc.ch/en/program/program/abstract/322
Meta 10 Technology
Leman Biotech's Metabolic Reprogramming Technology (Meta 10) is an innovative approach to combatting T-cell exhaustion. Preclinical studies shown its ability to activate the oxidative phosphorylation metabolism in terminally exhausted T cells, restoring their proliferative potential and cytotoxic activity. Promising preclinical results include tumor clearance in various mouse models and induction of stem-like immune memory cells. Leman Biotech has launched investigator initiated clinical trial for metabolically armed CD19 CAR-T therapy (Meta10-19 CAR-T) for patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) and acute B-lymphoblastic leukemia (r/r B-ALL) in early 2023. All patients treated with Meta 10-19 CAR-T have shown complete responses at a low dose, with minimal side effects. These findings underscore Meta 10's immense clinical potential.
About Leman Biotech
Leman Biotech is a clinical-stage cancer immunotherapy company co-founded by Professor Li Tang of the Swiss Federal Institute of Technology in Lausanne (EPFL) and AI-driven drug R&D leader XtalPi. The company combines innovative metabolic reprogramming technology with a cutting-edge AI drug discovery platform to develop next-generation cancer immunotherapies. The core technology, Meta 10, has the potential to cure solid tumors, as demonstrated in published research in top academic journals such as Nature Immunology and Nature Biotechnology. Additionally, it holds PCT patents covering major economies worldwide. Leman Biotech completed a successful angel plus round of financing, raising nearly $18 million in total, with plans for further financing underway. The company is committed to finding solutions to tackling the bottlenecks in cancer immunotherapy, improving response rates and efficacy, and making unremitting efforts to achieve the ultimate goal of curing cancer.
Website: https://www.lemanbio.com/en
